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Jurnal Keperawatan Indonesia
Articles
VIEWS: 907
10.7454/jki.v20i3.340
Submitted: 2015-07-09
Published: 2017-11-11

FORMULASI DAN UJI MANFAAT KRIM MINYAK JAHE MERAH DAN MINYAK CENGKEH TERHADAP NYERI HAID

University of Indonesia
Fakultas Farmasi Universitas Indonesia
Fakultas Farmasi Universitas Indonesia
primary dysmenorrhea Syzigium aromaticum Zingiber officinale var. Rubrum

Abstract

Menstruasi yang menimbulkan nyeri merupakan salah satu masalah ginekologi yang paling umum dialami wanita dari berbagai tingkat usia. Manajemen untuk mengatasi nyeri saat haid diantaranya adalah dengan mengonsumsi obat pereda nyeri haid. Saat ini masyarakat mulai beralih untuk menggunakan tanaman obat sebagai obat alternatif analgesik, diantaranya tanaman jahe merah merah (Zingiber officinale var. Rubrum) dan cengkeh (Syzigium aromaticum). Penelitian ini bertujuan untuk mengetahui pengaruh sediaan krim campuran minyak jahe merah (Zingiber officinale var. Rubrum) dan minyak cengkeh (Syzigium aromaticum) terhadap penurunan intensitas nyeri haid primer. Minyak jahe merah dan minyak cengkeh dibuat menjadi sediaan krim dengan konsentrasi berturut-turut 5% dan 3%. Uji stabilitas fisik sediaan krim dilakukan selama 12 minggu. Metode pada uji stabilitas meliputi pengamatan organoleptis (parameternya: pengamatan dan pencatatan pH, Cycling test, dan uji mekanik), dan uji keamanan kepada relawan menggunakan metode uji tempel. Uji manfaat dilakukan pada 30 siswi yang memenuhi kriteria sampel, dilakukan selama 3 jam pada area abdomen bagian bawah. Sediaan krim menunjukkan kestabilan selama 12 minggu dan hasil uji keamanan tidak menimbulkan iritasi sehingga aman digunakan secara topikal. Hasil uji manfaat diukur dengan parameter Visual Analogue Scale, Wong-Baker Faces Pain Rating Scale, frekuensi denyut nadi radialis, frekuensi pernapasan, menunjukkan sediaan krim  uji  mampu menurunkan intensitas nyeri  haid  primer. Krim uji memberikan pengaruh penurunan intensitas nyeri yang berbeda nyata dibandingkan krim plasebo, yaitu pada pemakaian krim setelah 3 jam.

 

Kata kunci: nyeri haid primer, Syzigium aromaticum, Zingiber officinale var. Rubrum

 

Abstract

 

Formulation and Benefits of Red Ginger Cream and Clove Oil to Dysmenorrhea. Painful menstruation is one of the most common gynecological problems experienced by women of all ages.  To overcome the pain during menstruation is by taking pain medication during menstruation. Nowaday, people are start to use herb as an alternative analgesic medicine, including red   ginger plant (Zingiber officinale var.Rubrum) and cloves (Syzigium aromaticum). This research aims to determine the effect of mixture cream between red ginger oil (Zingiber officinale var. Rubrum) and clove oil (Syzigium aromaticum) to reduce the intensity of primary Dysmenorrhea. Oil of red ginger and clove oils are made into cream with a concentration respectively 5% and 3%. Physical stability test for creams conducted over 12 weeks and safety testing to volunteers using the patch test. Benefit test carried out for 3 hours at the lower abdominal area. Formulations cream showed stability during 12 weeks and the results of safety test does not cause irritation which make safe to use topically. Benefit test results measured by Visual Analogue Scale parameter, Wong- Baker Faces Pain Rating Scale, the frequency of the radial pulse and respiratory rate, it shows the test cream capable of lowering the intensity of the primary dysmenorrhea. Test creams is able to decrease pain intensity and was significantly different compared to placebo cream where each effect of the cream is observed after 3 hours.

 

Keywords: primary dysmenorrhea, Syzigium aromaticum, Zingiber officinale var. Rubrum

References

  1. Adinma, E., & Adinman, J. (2008). Perceptions and practices on menstruation amongst Nigerian secondary school girls. African Journal of Reproductive Health, 12(1), 74-83.
  2. Ansel, H.C., & Stockton, S.J.P. (2016). Pharmaceutical calculations 15th Edition. Philadelphia: LWW.
  3. ACOG. (2015). Dysmenorrhea: Painful periods. Retrieved from: https://www.acog.org/-/media/For-Patients/faq046.pdf?dmc=1&ts=20180312T0414077027
  4. Calis, K.A. (2009). Dysmenorrhea. Avail. in URL: http://emedicine.medscape.com/article/253812-overview.
  5. Djajadisastra, J. (2003). Cosmetic Stability dalam Seminar Setengah Hari HIKI, 18 November 2003, Jakarta.
  6. Hawkins, S. M., & Matzuk, M. M. (2008). Menstrual cycle: Basic biology. Annals of the New York Academy of Sciences, 1135, 10–18. http://doi.org/10.1196/annals.1429.018
  7. Hediantoro, A., Hadisaputra, W., & Pramayadi, C.T. (2008). Masalah gangguan haid dan infertilitas. Jakarta: Fakultas Kedokteran Universitas Indonesia.
  8. Jaafarpour, M., Hatefi, M., Khajavikhan, J. (2015). Comparative effect of cinnamon and ibuprofen for treatment of primary dysmenorrhea: A randomized double-blind clinical trial. JCDR. 9 (4), 4–7.
  9. Kannan, P., Claydon, L. S., Miller, D., & Chapple, C. M. (2015). Vigorous exercises in the management of primary dysmenorrhea: A feasibility study. Disability & Rehabilitation, 37 (15), 1334–1339. doi:10.3109/09638288.2014.962108
  10. Kural, M., Noor, N. N., Pandit, D., Joshi, T., & Patil, A. (2015). Menstrual characteristics and prevalence of dysmenorrhea in college going girls. Journal of Family Medicine and Primary Care, 4 (3), 426–431. http://doi.org/10.4103/2249-4863.161345
  11. Lantz, R.C., Chen, G.J., Sarihan, M., Solyom, A.M., Jolad, S.D., Timmermann, B.N. (2007). The effect of extracts from ginger rhizome on inflammatory mediator production. Phytomedicine. 14: 123–128.
  12. Mahvash, N., Eidy, A., Mehdi, K., Zahra, M.T., Mani, M., Shahla, H. (2012). The Effect of Physical Activity on Primary Dysmenorrhea of Female University Students. World appl. Sci. J. 17(10): 1246-1252.
  13. Mitsui, T. (1997). New Cosmetic Science. Amsterdam: Elsevier.
  14. Omidvar, S., Bakouei, F., Amiri, F. N., & Begum, K. (2016). Primary dysmenorrhea and menstrual symptoms in Indian female students: Prevalence, impact and management. Global Journal of Health Science, 8(8), 135–144. http://doi.org/10.5539/gjhs.v8n8p135
  15. Ozgoli, G., Torkashvand, S., Salehi-Moghaddam, F., Borumandnia, N., Mojab, F., & Minooee, S. (2016). Comparison of peppermint and clove essential oil aroma on pain intensity and anxiety at first stage of labor. The Iranian Journal of Obstetrics, Gynecology and Infertility, 19(21), 1-11.
  16. Proctor, M., & Farquhar, C. (2006). Diagnosis and management of dysmenorrhoea. British Medical Journal, 332(7550), 1134–1138. doi: 10.1136/bmj.332.7550.1134
  17. Rehman, R., Akram, M., Akhtar, N., Jabeen, Q., Saeed, T., Shah, A.S.M., et al. (2011). Zingiber officinale Roscoe (Pharmacological Activity). J. of Med. Plants Res. 5: 344-348.
  18. Rizk, A.S. (2013). Effect of aromatherapy abdominal massage using peppermint versus ginger oils on primary dysmenorrhea among adolescent girls. J. of American Sci. 9(11): 597-605.
  19. Rusaydimanto, F. (2006). Efek analgesik ekstrak etanol bunga cengkeh (Caryophylli flos) pada mencit betina Galur Swiss-Webster. Karya Tulis Ilmiah. Tidak Dipublikasi. Fakultas Kedokteran, Universitas Kristen Maranatha.
  20. Samsudin, A. R., Kundre, R., & Onibala, F. (2016). Pengaruh pemberian kompres hangat memakai parutan jahe merah (Zingiber Officinale Roscoe Var Rubrum) terhadap penurunan skala nyeri pada penderita gout artritis di Desa Tateli Dua Kecamatan Mandolang Kabupaten Minahasa. eJurnal Keperawatan, 4(1). Diperoleh dari https://ejournal.unsrat.ac.id/index.php/jkp/article/viewFile/12128/11709
  21. Soja, S., Nayak, B. S., & Lobo, D. J. (2011). A Study to evaluate the effectiveness of acupressure on menstrual discomforts among adolescent girls. International Journal of Nursing Education, 3(2), 107-110.
  22. Sritoomma, N., Moyle, W., Cooke, M., & O’Dwyer, S. (2014). The effectiveness of Swedish massage with aromatic ginger oil in treating chronic low back pain in older adults: A randomized controlled trial. Complementary Therapies in Medicine, 22(1), 26-33.
  23. Towaha, J. (2012). Manfaat Eugenol Cengkeh dalam Berbagai Industri di Indonesia. Perspektif. 11(2); 79-90.
  24. Ugandar, R.E., & K. Deivi, K.S. (2013). Formulation and evaluation of natural palm oil-based vanishing cream. International Journal of Pharmaceutical Sciences and Research, 4(9); 3375-3380. DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(9).3375-80
  25. Widyatuti, W. (2008). Terapi komplementer dalam keperawatan. Jurnal Keperawatan Indonesia, 12(1), 53-57. doi:http://dx.doi.org/10.7454/jki.v12i1.200

How to Cite

Al Mansur, F. A., Djajadisastra, J., & Hanani, E. (2017). FORMULASI DAN UJI MANFAAT KRIM MINYAK JAHE MERAH DAN MINYAK CENGKEH TERHADAP NYERI HAID. Jurnal Keperawatan Indonesia, 20(3), 139–147. https://doi.org/10.7454/jki.v20i3.340