Abstract
Hypertension is one of the non-communicable diseases in Indonesia that is closely related to obesity. Therefore, this study aimed to determine the association between central obesity and hypertension in a cohort study group in Bogor City from 2011 to 2021. A retrospective cohort study design was employed, with multivariate Cox regression analysis performed using secondary data from the Risk Factors for Non-Communicable Diseases (FRPTM) Cohort Study. Among 3,586 samples, 879 incident cases of hypertension were observed by the end of follow-up, accounting for 24.5% of the at-risk population. The incidence rate of hypertension was 28 cases per 1000 people per year, with a cumulative incidence rate of 25%. Multivariate analysis found that people with central obesity (RR: 1.415; 1.181-1.694) had a higher risk of developing hypertension. Other covariates were present, including age (p = 0.000), obesity (p = 0.000), light smoking (p = 0.000), moderate smoking (p = 0.011), and heavy smoking (p = 0.035). The control of central obesity through routine waist circumference screening in primary health care can serve as an important opportunity to prevent hypertension.
References
- Bosomworth, N.J. (2019). Normal-weight central obesity: Unique hazard of the toxic waist. Canadian Family Physician Medecin de Famille Canadien, 65 (6), 399–408. Retrieved from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6738397/.
- Chen, L., Zhang, J., Zhou, N., Weng, J.Y., Bao, Z.Y., & Wu, L. (2023). Association of different obesity patterns with hypertension in US male adults: a cross-sectional study. Scientific Reports, 13 (1), 1–10. doi: 10.1038/s41598-023-37302-x.
- Dinas Kesehatan Kota Bogor. (2019). Profil kesehatan Kota Bogor 2018 [Bogor city health profile 2018]. Dinas Kesehatan Kota Bogor. Retrieved from: https://dinkes.kotabogor.go.id/search-result?search=PROFIL DINAS KESEHATAN 2018.
- Dinas Kesehatan Kota Bogor. (2022). Profil kesehatan Kota Bogor 2021 [Bogor city health profile 2021]. Dinas Kesehatan Kota Bogor. Retrieved from: https://dinkes.kotabogor.go.id/search-result?search=Profil%20Kesehatan%202021.
- El Meouchy, P., Wahoud, M., Allam, S., Chedid, R., Karam, W., & Karam, S. (2022). Hypertension related to obesity: Pathogenesis, characteristics and factors for control. International Journal of Molecular Sciences, 23 (20), 12305. doi: 10.3390/IJMS232012305.
- Fan, H., & Zhang, X. (2022). Effects of smoking intensity trajectory, cumulative smoking exposure, and the number of years since quitting on the subsequent risk of hypertension. The Journal of Clinical Hypertension, 24 (7), 937–944. doi: 10.1111/jch.14534.
- Fountoulakis, P., Theofilis, P., Tsalamandris, S., Antonopoulos, A.S., Tsioufis, P., Toutouzas, K., Oikonomou, E., Tsioufis, K., & Tousoulis, D. (2023). The cardiovascular consequences of electronic cigarette smoking: a narrative review. Expert Review of Cardiovascular Therapy, 21 (10), 651–661. doi: 10.1080/14779072.2023.2264179.
- Gao, N., Liu, T., Wang, Y., Chen, M., Yu, L., Fu, C., & Xu, K. (2023). Assessing the association between smoking and hypertension: Smoking status, type of tobacco products, and interaction with alcohol consumption. Frontiers in Cardiovascular Medicine, 10, 1027988. doi: 10.3389/fcvm.2023.1027988.
- Gebrina, M. (2024). Kenali dan kendalikan hipertensi, sebelum hipertensi mengendalikan kita [Control hypertension before it controls us. Retrieved from: https://ayosehat.kemkes.go.id/kenali-dan-kendalikan-hipertensi-sebelum-hipertensi-mengendalikan-kita. Accessed July 27, 2025.
- Haine, D., Dohoo, I., & Dufour, S. (2018). Selection and misclassification biases in longitudinal studies. Frontiers in Veterinary Science, 5 (99), 1–8. doi: 10.3389/fvets.2018.00099.
- Haryani, S., Sahar, J., & Sukihananto, S. (2016). Penyuluhan kesehatan langsung dan melalui media massa berpengaruh terhadap perawatan hipertensi pada usia dewasa di Kota Depok [The influence of direct health education and using mass media to treatment of hypertension at the age of adult]. Jurnal Keperawatan Indonesia, 19 (3), 161–168. doi: 10.7454/JKI.V19I3.469.
- Jaiswal, V., Chowdhury, F., Mashkoor, Y., Nasir, Y.M., Garimella, V., Van den Eynde, J., Huang, H.Y.R., Hanif, M., Kalra, K., Aronow, W., & Fonarow, G.C. (2025). Global and regional trends in hypertensive heart disease–related mortality: Insight from World Health Organization database. The American Journal of Cardiology, 257, 253–262. doi: 10.1016/j.amjcard.2025.09.025.
- Khanna, D., Welch, B.S., & Rehman, A. (2022). Pathophysiology of obesity. StatPearls Publishing. Retrieved from: https://www.ncbi.nlm.nih.gov/books/NBK572076/.
- Kesztyüs, D., Erhardt, J., Schönsteiner, D., & Kesztyüs, T. (2018). Therapeutic treatment for abdominal obesity in adults. Deutsches Ärzteblatt International, 115 (29–30), 487–493. doi: 10.3238/arztebl.2018.0487.
- Kristanti, D., & Prihartono, N. (2019). Obesity as a predictor of hypertension in adult population: A 14-years retrospective cohort study. Indian Journal of Public Health Research and Development, 10 (6), 491–497. doi: 10.5958/0976-5506.2019.01322.6.
- Ministry of Health Republic Indonesia. (2019). Laporan Riskesdas 2018 nasional [The 2018 national basic health research]. Retrieved from: https://repository.badankebijakan.kemkes.go.id/id/eprint/3514/.
- Ministry of Health Republic Indonesia. (2021). Laporan penelitian studi kohor faktor risiko penyakit tidak menular tahun 2021 [Cohort study research report on risk factors for non-communicable diseases, 2021]. Retrieved from: https://drive.google.com/file/d/1onS7anP-5u_m6nCqZ62wzoVJd57zlYCp/view?usp=sharing.
- Ministry of Health Republic Indonesia. (2024a). Daftar frequently asked questions (FAQ) pertanyaan yang sering ditanyakan seputar hasil utama SKI 2023 [Frequently asked questions list that often asked regarding Indonesia’s Health Survey report in 2023]. Retrieved from: https://www.badankebijakan.kemkes.go.id/daftar-frequently-asked-question-seputar-hasil-utama-ski-2023/hasil-utama-ski-2023/.
- Ministry of Health Republic Indonesia. (2024b). Menkes Budi: kalau ingin berumur panjang harus rutin cek kesehatan [Ministry of Health of Indonesia, Budi, said: If you want to life long, then you must have regular health checkups]. Retrieved from: https://kemkes.go.id/id/menkes-budi-kalau-ingin-berumur-panjang-harus-rutin-cek-kesehatan. Accessed July 27, 2025.
- Niu, J., & Seo, D.C. (2014). Central obesity and hypertension in Chinese adults: A 12-year longitudinal examination. Preventive Medicine, 62, 113–118. doi: 10.1016/J.YPMED.2014.02.012.
- Rahma, G., & Gusrianti, G. (2019). Hubungan obesitas sentral dengan hipertensi pada penduduk usia 25-65 tahun [The association between central obesity and hypertension in people aged 25—65 years]. Jurnal Ilmu Kesehatan, 3 (2), 118–122. doi: 10.33757/JIK.V3I2.239.
- Ren, H., Guo, Y., Wang, D., Kang, X., & Yuan, G. (2023). Association of normal-weight central obesity with hypertension: A cross-sectional study from the China health and nutrition survey. BMC Cardiovascular Disorders, 23 (1), 120. doi: 10.1186/s12872-023-03126-w.
- Rhee, E.J., Cho, J.H., Kwon, H., Park, S.E., Jung, J.H., Han, K.Do, Park, Y.G., Park, H.S., Kim, Y.H., Yoo, S.J., & Lee, W.Y. (2018). Association between abdominal obesity and increased risk for the development of hypertension regardless of physical activity: A nationwide population‐based study. The Journal of Clinical Hypertension, 20 (10), 1417–1426. doi: 10.1111/JCH.13389.
- Riyadina, W., Rahajeng, E., Pradono, J., Tuminah, S., Kristanti, D., Sudikno, S., Dryah, S.L., Sulistiowati, E., & Agita, S. (2020). Rekam jejak studi kohor faktor risiko penyakit tidak menular di kota Bogor [Track record of cohort studies on risk factors for noncommunicable diseases in the city of Bogor]. UI Publishing.
- Sudikno, S., Riyadina, W., & Rahajeng, E. (2018). Obesitas sentral pada orang dewasa: studi kohor prospektif di kota Bogor [Central obesity among adult: Prospective Cohort Study in Bogor]. Gizi Indonesia, 41 (2), 105–116. doi: 10.36457/GIZINDO.V41I2.276.
- Sulistiowati, E., & Sihombing, M. (2020). Risk factors for newly diagnosed hypertensive at non-diabetes participants: a cohort study in central Bogor, Indonesia. Proceedings from the 4th International Symposium on Health Research (ISHR 2019), 74–80. doi: 10.2991/AHSR.K.200215.015.
- Tenny, S., & Boktor, S. W. (2023). Incidence. StatPearls Publishing. Retrieved from: https://www.ncbi.nlm.nih.gov/books/NBK430746/.
- Trimarco, V., Izzo, R., Pacella, D., Trama, U., Manzi, M.V., Lombardi, A., Piccinocchi, R., Gallo, P., Esposito, G., Piccinocchi, G., Lembo, M., Morisco, C., Rozza, F., Santulli, G., & Trimarco, B. (2024). Incidence of new-onset hypertension before, during, and after the COVID-19 pandemic: a 7-year longitudinal cohort study in a large population. BMC Medicine, 22 (127), 1–13. doi: 10.1186/S12916-024-03328-9.
- Wong, M. C. S., Huang, J., Wang, J., Chan, P. S. F., Lok, V., Chen, X., Leung, C., Wang, H. H. X., Lao, X. Q., & Zheng, Z. J. (2020). Global, regional and time-trend prevalence of central obesity: a systematic review and meta-analysis of 13.2 million subjects. European Journal of Epidemiology, 35 (7), 673–683. doi: 10.1007/S10654-020-00650-3.
- World Health Organization (WHO). (2023). Hypertension. Retrieved from: https://www.who.int/news-room/fact-sheets/detail/hypertension. Accessed February 24, 2024.