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Jurnal Keperawatan Indonesia
Articles
VIEWS: 777
10.7454/jki.v13i1.226
Submitted: 2014-06-24
Published: 2010-03-24

Peningkatan Ekspresi Transforming Growth Factor Beta 1 (TGF β1) Pada Luka Diabetes Melitus Melalui Balutan Modern

konvensional luka diabetes melitus modern transforming growth factor beta 1

Abstract

Abstrak

Ekspresi transforming growth factor beta 1 pada luka diabetes melitus mengalami penurunan yang berdampak terhadap proses penyembuhan luka. Penelitian ini bertujuan untuk membandingkan perawatan luka modern dressing dengan metode konvensional terhadap ekspresi transforming growth factor beta 1 pada luka kaki diabetes melitus. Penelitian menggunakan quasi experimental pretest-posttest design dengan metode pengumpulan sampel secara consecutive sampling. Pengukuran ekspresi transforming growth factor beta 1 dilakukan pada hari ke-0 (pretest) dan ke-4 (posttest). Hasil penelitian didapatkan data pada kelompok modern terjadi peningkatan ekspresi transforming growth factor beta 1, sedangkan pada kelompok konvensional terjadi penurunan ekspresi transforming growth factor beta 1. Disimpulkan bahwa teknik perawatan luka secara modern mampu meningkatkan ekspresi transforming growth factor beta 1dibandingkan teknik konvensional pada luka kaki diabetes melitus.

 

Abstract

Reduction of expression of transforming growth factor beta 1 in diabetic ulcers affects overall wound healing. This study tried to draw a comparison of transforming growth factor beta 1 level between modern dressing and conventional dressing in diabetic foot ulcer. This study applied a quasi-experimental pretest-posttest design and a consecutive sampling method of data collection. Immunohistochemical analysis of transforming growth factor beta 1 level was measured on the day 0 (pretest) and the day 4 (posttest). In this study, the modern dressing application improves transforming growth factor beta 1 level. Meanwhile, the conventional dressing application decreases transforming growth factor beta 1 level. Thus, it can be concluded that the modern dressing application can increase transforming growth factor beta 1 level.

References

  1. Agren, M. S., & Werthen, M. (2007). The extracellular matrix in wound healing: A closer look at therapeutics for chronic wounds. International Journal of Low Extrem Wounds. Diperoleh dari http://ijl.sagepub.com/cgi/content/abstract/6/2/82.
  2. American Diabetes Association. (2005). Oral agents for type 2 diabetes: An update. Diperoleh dari www.diabetesjournals.org.
  3. Brazier, J. S., Stubbs, S. L. J., & Duerden, B. I. (1999). Metronidazole resistance among clinical isolates belonging to the Bacteroides fragilis group: Time to be concerned? Journal Antimicrob Chemother. Diperoleh dari http://jac.ox fordjournals.org/cgi/content/full/44/4/580.
  4. Bryan, J. (2004). Moist wound healing: A concept that changed our practice, Journal of Wound Care. Diperoleh dari http://www.woundconsultant.com/files/Moist_Wound_Healing2.pdf.
  5. Collo, G., & Pepper, M. S. (1999). Endhotelial cell integrin a5â1 expression is modulated by cytokines and during migration in vitro, Journal Cell Science. Diperoleh dari www.sagepub.com.
  6. Dealey, C. (2005). The care of wounds: A guide for nurses. Victoria: Blackwell Publishing.
  7. Faler, B. J., Macsata, R. A., & Plummer, D. (2006). Focus on basic science: Transforming growth factor-ß and wound healing. Sage Publication. Diperoleh dari http://pvs.sagepub.com.
  8. Genna, J. G. (2003). Neuropathic foot ulcers. Dalam Milne, C. T., Corbett, L. Q., & Dubuc, D. L. (Eds.), Wound, ostomy, and continence nursing secrets (Hal. 175). Philadelphia: Hanley & Belvus, Inc.
  9. Jude, Blakytny, Bulmer, Boulton, & Ferguson. (2002). Abstract: Transforming growth factor-beta 1, 2, 3 and receptor type I and II in diabetic foot ulcers. Journal of Diabetes UK. Doi: 10.1046/j.1464-5491. 2002.00692.x. Diperoleh dari http://www. blackwell synergy. com/.
  10. Khan, M. N., & Naqvi, A. H. (2005). Antiseptics, iodine, povidone iodine and traumatic wound cleansing. Tissue Viability Society. Diperoleh dari www.tvs.org.uk/sitedocument/Khan_16.pdf.
  11. Kolcaba. (2008). The web site devoted to the concept of comfort in nursing. Diperoleh dari http://www.thecomfortline.com/index. htm.
  12. Mauviel, A. (2009). Transforming growth factor-ß signaling in skin: Stromal to epithelial cross-talk, Journal of Investigative Dermatology. Diperoleh dari http://www.nature.com/jid/journal/v129/n1/pdf/jid2008385a.pdf.
  13. NLLIC. (2008). Diabetes and lower extremity amputations, Knoxville: Ampute Coalition of America (ACA). Diperoleh dari www.amputee-coalition.org/nllic_topic/06 08_bilateral_lowe r_extremity.html.
  14. Perkeni. (2006). Konsensus pengelolaan dan pencegahan diabetes melitus tipe 2 di Indonesia. Diperoleh dari www.scribd.com.
  15. Perkeni. (2009). Pedoman penatalaksanaan kaki diabetik. Jakarta: PB Perkeni.
  16. Sampaio, C. P. P., Simoes, M. L. P. B, Trindade, L. C. T., Farias, R. E., Pierin, R. J., Martins, R. C. (2009). Inflammatory alterations provoked by metronidazole in wounds: an experimental study in rats. Jornal Vascular Brasileiro. Diperoleh dari www.scielo.br/scielo.php?pid=S1677 script=sci_arttext.
  17. Selim, P. (2002). Promoting evidence-based nursing practice – The use of antiseptics in wound management: A community nursing focus. RDNS. Diperoleh dari http://www. rdns.net.au.
  18. The Joanna Briggs Institute. (2006). Solutions, techniques and pressure in wound cleansing. Best Practice. Blackwell Publishing. Diperoleh dari http://www.joannabriggs.edu.au/pdf/BPISEng_10.pdf.
  19. Wild, S., Roglic, G., Green, A., Sicree, R., & King, H. (2004). Global prevalence of diabetes: Estimates for the year 2000 and projections for 2030, Diabetes Care, 27 (5). Diperoleh dari http://www.who.int/diabetes/facts/en/diabcare0504.pdf.
  20. Wood, G.L., & Haber, J. (2006). Nursing research. St. Louis: Mosby.

How to Cite

Kristianto, H., Nurachmah, E., & Gayatri, D. (2010). Peningkatan Ekspresi Transforming Growth Factor Beta 1 (TGF β1) Pada Luka Diabetes Melitus Melalui Balutan Modern. Jurnal Keperawatan Indonesia, 13(1), 20–25. https://doi.org/10.7454/jki.v13i1.226