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Articles
VIEWS: 15
Published: 2026-07-30

Early Post-Cesarean Anxiety, Nausea, Vomiting, and Pain Under Spinal Anesthesia: Trajectories and Modifiable Predictors

School of Nursing, Faculty of Health, Universitas Harapan Bangsa, Indonesia
Study Program of Nursing, Faculty of Medicine, Universitas Tanjungpura, Indonesia
School of Nursing, Faculty of Health, Universitas Harapan Bangsa, Indonesia
School of Nursing, Faculty of Health, Universitas Harapan Bangsa, Indonesia
School of Nursing Anesthesia, Oregon Health and Science University, Portland, United States
Department of Nursing, Anesthesia, Buffalo General Medical Center, Buffalo, United States
School of Nursing, Faculty of Health, Universitas Sahid Surakarta, Indonesia
School of Nursing, Faculty of Health, Universitas Aisyah Pringsewu, Indonesia
School of Nursing, Faculty of Health, Universitas Harapan Bangsa, Indonesia; School of Nursing, College of Nursing, Taipei Medical University, Taiwan
anesthesia anxiety pain post-operative caesarean section postoperative nausea and vomiting spinal anesthesia

Abstract

Recovery after caesarean under spinal anesthesia remains a quality gap, with scarce evidence on modifiable anesthetic practices improving recovery. Data linking the neuraxial technique, nausea, anxiety, and pain remain limited. The objective of this study was to describe postoperative nausea and vomiting, anxiety, and pain at 6, 12, and 24 hours after caesarean section under spinal anesthesia and to examine whether intrathecal adjuvant use, sensory block level, fasting duration, and American Society of Anesthesiologists (ASA) physical status were associated with these outcomes. Cross-sectional study across five hospitals; 534 women undergoing caesarean under spinal anesthesia. Exposures: intrathecal adjuvant, sensory level (≤ T6 and > T6), nil per os (NPO) time, and ASA class. Outcomes: postoperative nausea and vomiting (PONV) using Rhodes Index of Nausea, Vomiting, and Retching (RINVR), anxiety using State-Trait Anxiety-State STAI-S), pain at 6,12,24 h; generalized estimating equations Poisson and linear models. A total of 534 women completed the study (mean age, 31.8 years; mean body mass index, 29.3). Symptom burden was greatest in the early postoperative period: postoperative nausea and vomiting and pain were highest at 6 hours, whereas anxiety peaked at 12 hours. By 24 hours, symptoms had declined, although substantial proportions of women continued to report nausea and pain. Better ASA physical status (class I-II) was associated with lower RINVR and STAI-S. These findings suggest that modifiable perioperative factors may help inform strategies to improve early post-caesarean recovery and guide postoperative nursing monitoring and symptom management.

References

  1. Adha, F.R., & Komalasari, D.R. (2024). Validity and reliability of the numeric rating scale in non-myogenic low back pain patients. Academic Physiotherapy Conference Proceeding, 414–422. Retrieved from: https://proceedings.ums.ac.id/apc/article/view/4396.
  2. American Society of Anesthesiologists. (2025). American Society of Anesthesiologists statement on ASA Physical Status Classification System. Anesthesiology Open, 1 (1), e0002. 10.1097/AO9.0000000000000002.
  3. Barud, A.A., Ali, I.A., Hilowle, N.M., Hassan, H.B., & Osman, I.M. (2025). Incidence and risk factors of hypotension in cesarean section patients under spinal anesthesia at a referral hospital in Mogadishu, Somalia. BMC Pregnancy and Childbirth, 25, 883. doi: 10.1186/s12884-025-08024-x.
  4. Benjhawaleemas, P., Sakolnagara, B.B.N., Tanasansuttiporn, J., Chatmongkolchart, S., & Oofuvong, M. (2024). Risk prediction score for high spinal block in patients undergoing cesarean delivery: A retrospective cohort study. BMC Anesthesiology, 24, 406. doi; 10.1186/s12871-024-02799-w.
  5. Betran, A.P., Ye, J., Moller, A.-B., Souza, J.P., & Zhang, J. (2021). Trends and projections of caesarean section rates: Global and regional estimates. BMJ Global Health, 6 (6), e005671. doi: 10.1136/bmjgh-2021-005671
  6. Caballero‑Lozada, A.F., Gómez, J.M., Torres‑Mosquera, A., González‑Carvajal, Á., Marín‑Prado, A., Zorrilla‑Vaca, A., Zhao, X., & Li, J. (2022). Impacts of intrathecal fentanyl on the incidence of postoperative nausea/vomiting: Systematic review and meta‑analysis of randomized studies. Journal of Anaesthesiology Clinical Pharmacology, 38 (3), 391-398. doi: 10.4103/joacp.joacp_443_20
  7. Charan, J., & Biswas, T. (2013). How to calculate sample size for different study designs in medical research? Indian Journal of Psychological Medicine, 35 (2), 121–126. doi: 10.4103/0253-7176.116232.
  8. Demilew, B.C., Zurbachew, N., Getachew, N., Mekete, G., & Teshome, D. (2025). Prevalence and associated factors of intraoperative nausea and vomiting of mothers who gave birth with cesarean section under regional anesthesia: A systematic review and meta-analysis; 2023. BMC Pregnancy and Childbirth, 25, 244. doi: 10.1186/s12884-025-07363-z.
  9. Faul, F., Erdfelder, E., Buchner, A., & Lang, A.-G. (2009). Statistical power analyses using G*Power 3.1: Tests for correlation and regression analyses. Behavior Research Methods, 41, 1149–1160. doi: 10.3758/BRM.41.4.1149.
  10. Gerbershagen, H.J., Rothaug, J., Kalkman, C.J., & Meissner, W. (2011). Determination of moderate-to-severe postoperative pain on the numeric rating scale: A cut-off point analysis applying four different methods. British Journal of Anaesthesia, 107 (4), 619–626. doi: 10.1093/bja/aer195.
  11. Hannola, K., Hoppu, S., Mennander, S., Huhtala, H., Laivuori, H., & Tihtonen, K. (2021). Obstetric early warning system to predict maternal morbidity of pre-eclampsia, postpartum hemorrhage and infection after birth in high-risk women: A prospective cohort study. Midwifery, 99, 103015. doi: 10.1016/j.midw.2021.103015.
  12. Hatter, K.H., Shugart, N.W., Paladugu, N., Nitchie, H., Wolf, B., & Hebbar, L. (2025). Low dose intrathecal morphine for post-cesarean analgesia with scheduled multimodal pain regimen: A prospective, randomized, open blinded end-point study. International Journal of Obstetric Anesthesia, 62, 104361. doi: 10.1016/j.ijoa.2025.104361.
  13. Higashi, M., Shirozu, K., Sumie, M., Ando, T., Akasaka, T., Yumoto, Y., Hojo, S., & Yamaura, K. (2025). Prevention of spinal anaesthesia-induced hypotension during caesarean section using noninvasive cardiac output monitoring: A randomised clinical trial. European Journal of Anaesthesiology Intensive Care, 4 (5), e0086. doi: 10.1097/EA9.0000000000000086.
  14. Huh, H. (2023). Postoperative nausea and vomiting in spinal anesthesia. Korean Journal of Anesthesiology, 76 (2), 87–88. doi: 10.4097/kja.23157.
  15. Ibrahem, A.F., Melkie, T.B., Filatie, T.D., Tegegne, B.A., & Admassie, B.M. (2024). Practice of enhanced recovery after cesarean delivery in resource-limited setting. Annals of Medicine & Surgery, 86 (1), 139–145. doi: 10.1097/MS9.0000000000001571.
  16. Ishida, A., Ida, M., Kinomoto, A., Naito, Y., & Kawaguchi, M. (2025). Association of preoperative anxiety and depression with quality of recovery after caesarean delivery: A prospective observational study. JA Clinical Reports, 11, 19. doi: 10.1186/s40981-025-00782-z.
  17. Kang, H. (2021). Sample size determination and power analysis using the G*Power software. Journal of Educational Evaluation for Health Professions, 18, 17. doi: 10.3352/jeehp.2021.18.17.
  18. Karataş, S.Ş., Bulut, O.K., & Öner, S.F. (2025). The effect of different information methods on patients’ anxiety and preference for spinal versus general anesthesia in a Turkish cohort of women scheduled for cesarean delivery: A prospective observational study. International Journal of Obstetric Anesthesia, 63, 104689. doi: 10.1016/j.ijoa.2025.104689.
  19. Kim, J.-H., Kim, N., Lee, S.-K., & Kwon, Y.-S. (2022). Effect of pregnancy on postoperative nausea and vomiting in female patients who underwent nondelivery surgery: Multicenter retrospective cohort study. International Journal of Environmental Research and Public Health, 19 (22), 15132. doi: 10.3390/ijerph192215132.
  20. Kim, T.H., Choi, B.M., Chin, J.H., Lee, M.S., Kim, D.H., & Noh, G.J. (2007). The reliability and validity of the rhodes index of nausea, vomiting and retching in postoperative nausea and vomiting. Korean Journal of Anesthesiology, 52 (6), S59-S65. doi: 10.4097/kjae.2007.52.6.S59.
  21. Liang, K.-Y., & Zeger, S.L. (1986). Longitudinal data analysis using generalized linear models. Biometrika, 73 (1), 13–22. doi: 10.1093/biomet/73.1.13.
  22. Liu, Y., Zhong, H., Dai, Z., Huang, Y., Liu, Y., He, H., Liao, Y., & Liu, W. (2025). Predicting postoperative nausea and vomiting after cesarean section: A nomogram model combined with gastric ultrasound. BMC Anesthesiology, 25, 64. doi: 10.1186/s12871-025-02936-z.
  23. Lorato, S.S., Agide, F.D., Getahun, G.K., Seid, K., Wondimagne, Y.A., Desalegn, M., Rundasa, D.T., Godie, Y., Yadate, T., Wolde, Y., & Bogale, E.K. (2025). Incidence and predictors of post spinal anesthesia-induced hypotension for cesarean section in Ethiopia: A systematic review and meta-analysis. Perioperative Care and Operating Room Management, 40, 100541. doi: 10.1016/j.pcorm.2025.100541.
  24. Na, H.-S. (2025). Optimizing maternal recovery: Insights into enhanced recovery after cesarean delivery. Anesthesia and Pain Medicine, 20 (2), 101–108. doi: 10.17085/apm.25211.
  25. Paliwal, N., & Khan, I.A. (2025). Exploring variability in spinal anesthesia levels achieved during cesarean section deliveries: A narrative review. Cureus, 17 (7), e88429. doi: 10.7759/cureus.88429.
  26. Ravishankar, N., Kalingarayar, S., & Govarthanan, S. (2025). Comparison of perioperative single-dose systemic dexamethasone versus placebo for prolongation of postoperative analgesia in term parturients undergoing cesarean section under spinal anesthesia. Cureus, 17 (8), e90011. doi: 10.7759/cureus.90011.
  27. Rubin, D.B. (1987). Multiple imputation for nonresponse in surveys (1st edition). Wiley Online Library.
  28. Rüggeberg, A., Meybohm, P., & Nickel, E.A. (2024). Preoperative fasting and the risk of pulmonary aspiration—A narrative review of historical concepts, physiological effects, and new perspectives. BJA Open, 10, 100282. doi: 10.1016/j.bjao.2024.100282.
  29. Setiawati, Y., Wahyuhadi, J., Joestandari, F., Maramis, M.M., & Atika, A. (2021). Anxiety and resilience of healthcare workers during COVID-19 pandemic in Indonesia. Journal of Multidisciplinary Healthcare, 14, 1–8. doi: 10.2147/JMDH.S276655.
  30. Shebl, M.A., Toraih, E., Shebl, M., Tolba, A.M., Ahmed, P., Banga, H.S., Orz, M., Tammam, M., Saadalla, K., Elsayed, M., Kamal, M., Abdulla, M., Eldessouky, A.I., Moustafa, Y.T., Mohamed, O.A., & Aiash, H. (2025). Preoperative anxiety and its impact on surgical outcomes: A systematic review and meta-analysis. Journal of Clinical and Translational Science, 9 (1), e33. doi: 10.1017/cts.2025.6.
  31. Singh, N.P., Makkar, J.K., Jafra, A., Verma, P., & Singh, P.M. (2022). The effect of two groups of intrathecal fentanyl doses on analgesic outcomes and adverse effects in parturients undergoing cesarean delivery: A systematic review and meta-analysis of randomized controlled trials with trial sequential analysis. International Journal of Obstetric Anesthesia, 50, 103270. doi: 10.1016/j.ijoa.2022.103270.
  32. Sultan, P., Monks, D.T., Sharawi, N., Bamber, J., Panelli, D.M., Sauro, K.M., Shah, P.S., Muraca, G.M., Metcalfe, A., Wood, S.L., Jago, C.A., Daly, S., Blake, L.E.A., Macones, G.A., Caughey, A.B., Wilson, R.D., & Nelson, G. (2025). Guidelines for postoperative care in cesarean delivery: Enhanced recovery after surgery society recommendations (part 3)-2025 update. American Journal of Obstetrics and Gynecology, 233 (6), S184-S198. doi: 10.1016/j.ajog.2025.01.038.
  33. Tluczek, A., Henriques, J.B., & Brown, R.L. (2009). Support for the reliability and validity of a six-item state anxiety scale derived from the state-trait anxiety inventory. Journal of Nursing Measurement, 17 (1), 19–28. doi: 10.1891/1061-3749.17.1.19.
  34. Verbeeck, J., Geroldinger, M., Thiel, K., Hooker, A.C., Ueckert, S., Karlsson, M., Bathke, A.C., Bauer, J.W., Molenberghs, G., & Zimmermann, G. (2023). How to analyze continuous and discrete repeated measures in small-sample cross-over trials? Biometrics, 79 (4), 3998–4011. doi: 10.1111/biom.13920.
  35. von, E.E., Altman, D., Egger, M., Pocock, S., Gøtzsche, P., & Vandenbroucke, J. (2007). The strengthening the reporting of observational studies in epidemiology (strobe) statement: Guidelines for reporting observational studies. Journal of Clinical Epidemiology, 61 (4), 344-349. doi: 10.1016/j.jclinepi.2007.11.008.
  36. Walker, M., Sobel, M., Siddiqi, N., Carvalho, J.C.A., Jahan, N., Santini, S., Watts, N., Dart, K., Wang, S., Huszti, E., & Thomas, J. (2025). Implementation of enhanced recovery after surgery for caesarean delivery: A quality improvement initiative. BMJ Open Quality, 14 (3), e003391. doi: 10.1136/bmjoq-2025-003391.
  37. Wang, L., Huang, J., Hu, H., Chang, X., & Xia, F. (2024). Commonly used antiemetics for prophylaxis of postoperative nausea and vomiting after caesarean delivery with neuraxial morphine: a network meta-analysis. British Journal of Anaesthesia, 132 (6), 1274–1284. doi: 10.1016/j.bja.2024.03.010.
  38. White, I.R., Royston, P., & Wood, A.M. (2011). Multiple imputation using chained equations: Issues and guidance for practice. Statistics in Medicine, 30 (4), 377–399. doi: 10.1002/sim.4067.
  39. WHO. (2021). Caesarean section rates continue to rise, amid growing inequalities in access. Retrieved from: https://www.who.int/news/item/16-06-2021-caesarean-section-rates-continue-to-rise-amid-growing-inequalities-in-access.
  40. WHO. (2025a). Maternal mortality. Retrieved from: https://www.who.int/news-room/fact-sheets/detail/maternal-mortality.
  41. WHO. (2025b). Trends in maternal mortality 2000 to 2023: Estimates by WHO, UNICEF, UNFPA, World Bank Group, and UNDESA/Population Division. Retrieved from: https://www.who.int/publications/i/item/9789240108462.
  42. Wilson, R.D., Monks, D.T., Sharawi, N., Bamber, J., Panelli, D.M., Sauro, K.M., Shah, P.S., Muraca, G.M., Metcalfe, A., Wood, S.L., Jago, C.A., Daly, S., Blake, L.E.A., Macones, G.A., Caughey, A.B., Sultan, P., & Nelson, G. (2026). Guidelines for antenatal and preoperative care in cesarean delivery: Enhanced Recovery After Surgery Society recommendations (part 1)—2025 update. American Journal of Obstetrics and Gynecology, 233 (6), S153-S169. doi: 10.1016/j.ajog.2025.01.014.
  43. Zahroh, R.I., Hazfiarini, A., Martiningtyas, M.A., Ekawati, F.M., Emilia, O., Cheong, M., Betran, A.P., Homer, C.S., & Bohren, M.A. (2024). Rising caesarean section rates and factors affecting women’s decision-making about mode of birth in Indonesia: A longitudinal qualitative study. BMJ Global Health, 9 (6), e014602. doi: 10.1136/bmjgh-2023-014602.
  44. Zhang, J., Che, J., Sun, X., Li, Y., & Ren, W. (2025). Analysis of the risk difference in post-spinal anesthesia hypotension between primiparas and multiparas in cesarean section. Frontiers in Surgery, 12, 1617342. doi: 10.3389/fsurg.2025.1617342.
  45. Zou, G. (2004). A modified poisson regression approach to prospective studies with binary data. American Journal of Epidemiology, 159 (7), 702–706. doi: 10.1093/aje/kwh090.

How to Cite

Susanti, I., Firdaus, E. K., Sebayang, S. M., Andini, A., Berg, A. D., Atwood, M., Sumarni, R., Mesya, M., & Burhan, A. (2026). Early Post-Cesarean Anxiety, Nausea, Vomiting, and Pain Under Spinal Anesthesia: Trajectories and Modifiable Predictors. Jurnal Keperawatan Indonesia, 29(2), 108–125. https://doi.org/10.7454/jki.v29i2.2207